GLUT-1 IS A PROMISING TARGET FOR ATP DEPLETION ON DIABETIC ENERGY DEFICIENCY SYNDROME

GLUT-1 IS A PROMISING TARGET FOR ATP DEPLETION ON DIABETIC ENERGY DEFICIENCY SYNDROME

Diabetes is a metabolic syndrome which characterized with insulin insensitivity, lack of GLUT-4 membrane presentation and ATP deficiency. ATP is needed for substrate phosphorylation, signalling pathways, protein translation and cellular survival. Since GLUT-1 was discovered as alternative glucose tr...

Full description

Bibliographic Details
Main Authors: Bambang Purwanto, Harjanto Harjanto, Elyana Asnar
Format: Article
Language:English
Published: Universitas Airlangga 2017-11-01
Series:Folia Medica Indonesiana
Subjects:
Diabetes
glucose transporter
energy deficiency
eccentric
streptozotocin
Online Access:https://e-journal.unair.ac.id/FMI/article/view/6443
id doaj-0b53ae5a6339474cb323dea767b9a7e8
record_format Article
spelling doaj-0b53ae5a6339474cb323dea767b9a7e82020-11-24T21:22:27ZengUniversitas AirlanggaFolia Medica Indonesiana2355-83932599-056X2017-11-0153317717910.20473/fmi.v53i3.64433604GLUT-1 IS A PROMISING TARGET FOR ATP DEPLETION ON DIABETIC ENERGY DEFICIENCY SYNDROMEBambang Purwanto0Harjanto Harjanto1Elyana Asnar2Department of Medical Physiology, Faculty of Medicine, Airlangga University, SurabayaDepartment of Medical Physiology, Faculty of Medicine, Airlangga University, SurabayaDepartment of Medical Physiology, Faculty of Medicine, Airlangga University, SurabayaDiabetes is a metabolic syndrome which characterized with insulin insensitivity, lack of GLUT-4 membrane presentation and ATP deficiency. ATP is needed for substrate phosphorylation, signalling pathways, protein translation and cellular survival. Since GLUT-1 was discovered as alternative glucose transporter on muscle membrane, some studies started to investigate it more. This study aimed to investigate GLUT-1 presentation on diabetes muscle membrane of rat model in time. Diabetes was obtained from a 50 mg/kg B.W of streptozotocin intra peritoneal injection on rat. We found that GLUT-1 presentation increased significantly in time of diabetic stages. It correlated negatively with GLUT-4 presentation and mortality. Eccentric downhill running on diabetic rat model improved GLUT-1 presentation and blood glucose level. It was promising for diabetes management therapy at the future.https://e-journal.unair.ac.id/FMI/article/view/6443Diabetesglucose transporterenergy deficiencyeccentricstreptozotocin
collection DOAJ
language English
format Article
sources DOAJ
author Bambang Purwanto
Harjanto Harjanto
Elyana Asnar
spellingShingle Bambang Purwanto
Harjanto Harjanto
Elyana Asnar
GLUT-1 IS A PROMISING TARGET FOR ATP DEPLETION ON DIABETIC ENERGY DEFICIENCY SYNDROME
Folia Medica Indonesiana
Diabetes
glucose transporter
energy deficiency
eccentric
streptozotocin
author_facet Bambang Purwanto
Harjanto Harjanto
Elyana Asnar
author_sort Bambang Purwanto
title GLUT-1 IS A PROMISING TARGET FOR ATP DEPLETION ON DIABETIC ENERGY DEFICIENCY SYNDROME
title_short GLUT-1 IS A PROMISING TARGET FOR ATP DEPLETION ON DIABETIC ENERGY DEFICIENCY SYNDROME
title_full GLUT-1 IS A PROMISING TARGET FOR ATP DEPLETION ON DIABETIC ENERGY DEFICIENCY SYNDROME
title_fullStr GLUT-1 IS A PROMISING TARGET FOR ATP DEPLETION ON DIABETIC ENERGY DEFICIENCY SYNDROME
title_full_unstemmed GLUT-1 IS A PROMISING TARGET FOR ATP DEPLETION ON DIABETIC ENERGY DEFICIENCY SYNDROME
title_sort glut-1 is a promising target for atp depletion on diabetic energy deficiency syndrome
publisher Universitas Airlangga
series Folia Medica Indonesiana
issn 2355-8393
2599-056X
publishDate 2017-11-01
description Diabetes is a metabolic syndrome which characterized with insulin insensitivity, lack of GLUT-4 membrane presentation and ATP deficiency. ATP is needed for substrate phosphorylation, signalling pathways, protein translation and cellular survival. Since GLUT-1 was discovered as alternative glucose transporter on muscle membrane, some studies started to investigate it more. This study aimed to investigate GLUT-1 presentation on diabetes muscle membrane of rat model in time. Diabetes was obtained from a 50 mg/kg B.W of streptozotocin intra peritoneal injection on rat. We found that GLUT-1 presentation increased significantly in time of diabetic stages. It correlated negatively with GLUT-4 presentation and mortality. Eccentric downhill running on diabetic rat model improved GLUT-1 presentation and blood glucose level. It was promising for diabetes management therapy at the future.
topic Diabetes
glucose transporter
energy deficiency
eccentric
streptozotocin
url https://e-journal.unair.ac.id/FMI/article/view/6443
work_keys_str_mv AT bambangpurwanto glut1isapromisingtargetforatpdepletionondiabeticenergydeficiencysyndrome
AT harjantoharjanto glut1isapromisingtargetforatpdepletionondiabeticenergydeficiencysyndrome
AT elyanaasnar glut1isapromisingtargetforatpdepletionondiabeticenergydeficiencysyndrome
_version_ 1725995599564636160

Similar Items