Hepatitis B Virus X Protein (HBx) Suppresses Transcription Factor EB (TFEB) Resulting in Stabilization of Integrin Beta 1 (ITGB1) in Hepatocellular Carcinoma Cells

Hepatitis B Virus X Protein (HBx) Suppresses Transcription Factor EB (TFEB) Resulting in Stabilization of Integrin Beta 1 (ITGB1) in Hepatocellular Carcinoma Cells

Hepatitis B virus (HBV) infection is a major etiological risk for the incidence of hepatocellular carcinoma (HCC), and HBV X protein (HBx) is essential for oncogenic transformation. It is not known that if HBx can sabotage the lysosomal system for transformation and tumorigenesis, or its mechanism i...

Full description

Bibliographic Details
Main Authors: Chunyan Zhang, Huan Yang, Liwei Pan, Guangfu Zhao, Ruofei Zhang, Tianci Zhang, Zhixiong Xiao, Ying Tong, Yi Zhang, Richard Hu, Stephen J. Pandol, Yuan-Ping Han
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
HBx
TFEB
lysosome biogenesis
ITGB1
cysteine protease
hepatocellular carcinoma (HCC)
Online Access:https://www.mdpi.com/2072-6694/13/5/1181

Internet

https://www.mdpi.com/2072-6694/13/5/1181

Similar Items