APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy
DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine setting to generate heteroclitic neoepitopes, enhancing...
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Nature Publishing Group
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14568-7 |
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doaj-0b522666697f4ba891fb72be5cba002f2021-05-11T09:10:17ZengNature Publishing GroupNature Communications2041-17232020-02-0111111410.1038/s41467-020-14568-7APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapyChristopher B. Driscoll0Matthew R. Schuelke1Timothy Kottke2Jill M. Thompson3Phonphimon Wongthida4Jason M. Tonne5Amanda L. Huff6Amber Miller7Kevin G. Shim8Amy Molan9Cynthia Wetmore10Peter Selby11Adel Samson12Kevin Harrington13Hardev Pandha14Alan Melcher15Jose S. Pulido16Reuben Harris17Laura Evgin18Richard G. Vile19Department of Molecular Medicine, Mayo ClinicDepartment of Molecular Medicine, Mayo ClinicDepartment of Molecular Medicine, Mayo ClinicDepartment of Molecular Medicine, Mayo ClinicDepartment of Molecular Medicine, Mayo ClinicDepartment of Molecular Medicine, Mayo ClinicDepartment of Molecular Medicine, Mayo ClinicDepartment of Molecular Medicine, Mayo ClinicDepartment of Molecular Medicine, Mayo ClinicDepartment of Biochemistry, Molecular Biology & Biophysics, University of MinnesotaCenter for Cancer and Blood Disorders, Phoenix Children’sLeeds Institute of Cancer and Pathology (LICAP), Faculty of Medicine and Health, St James’ University Hospital, University of LeedsLeeds Institute of Cancer and Pathology (LICAP), Faculty of Medicine and Health, St James’ University Hospital, University of LeedsTargeted Therapy Team, Division of Radiotherapy and Imaging, The Institute of Cancer ResearchPostgraduate Medical School, University of SurreyTranslational Immunotherapy Team, Division of Radiotherapy and Imaging, The Institute of Cancer ResearchDepartment of Ophthalmology, Mayo ClinicDepartment of Biochemistry, Molecular Biology & Biophysics, University of MinnesotaDepartment of Molecular Medicine, Mayo ClinicDepartment of Molecular Medicine, Mayo ClinicDNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine setting to generate heteroclitic neoepitopes, enhancing sensitivity to immunotherapy.https://doi.org/10.1038/s41467-020-14568-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Christopher B. Driscoll Matthew R. Schuelke Timothy Kottke Jill M. Thompson Phonphimon Wongthida Jason M. Tonne Amanda L. Huff Amber Miller Kevin G. Shim Amy Molan Cynthia Wetmore Peter Selby Adel Samson Kevin Harrington Hardev Pandha Alan Melcher Jose S. Pulido Reuben Harris Laura Evgin Richard G. Vile |
| spellingShingle |
Christopher B. Driscoll Matthew R. Schuelke Timothy Kottke Jill M. Thompson Phonphimon Wongthida Jason M. Tonne Amanda L. Huff Amber Miller Kevin G. Shim Amy Molan Cynthia Wetmore Peter Selby Adel Samson Kevin Harrington Hardev Pandha Alan Melcher Jose S. Pulido Reuben Harris Laura Evgin Richard G. Vile APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy Nature Communications |
| author_facet |
Christopher B. Driscoll Matthew R. Schuelke Timothy Kottke Jill M. Thompson Phonphimon Wongthida Jason M. Tonne Amanda L. Huff Amber Miller Kevin G. Shim Amy Molan Cynthia Wetmore Peter Selby Adel Samson Kevin Harrington Hardev Pandha Alan Melcher Jose S. Pulido Reuben Harris Laura Evgin Richard G. Vile |
| author_sort |
Christopher B. Driscoll |
| title |
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy |
| title_short |
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy |
| title_full |
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy |
| title_fullStr |
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy |
| title_full_unstemmed |
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy |
| title_sort |
apobec3b-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-02-01 |
| description |
DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine setting to generate heteroclitic neoepitopes, enhancing sensitivity to immunotherapy. |
| url |
https://doi.org/10.1038/s41467-020-14568-7 |
| work_keys_str_mv |
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