Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients
Aim. To estimate a relationship between the intima-media thickness (TIM), cardiovascular risk (CVR) factors, and the level of C-reactive protein (CRP) in gouty patients. Subjects and methods. Eighty-nine patients at an interattack interval were examined. The patients' mean age was 46.0 ± 11.4 y...
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"Consilium Medicum" Publishing house
2009-10-01
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doaj-0b50cd590b444d359d2a018d9eb35cc42020-11-25T03:06:08Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422009-10-018110454927551Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patientsAnna Evgen'evna Il'inaEvgeniya Innokent'evna VarfolomeevaAleksandr Viktorovich VolkovEvelina Semenovna MachElena Nikolaevna AleksandrovaAleksandr Aleksandrovich NovikovEkaterina Valerievna Il'inykhViktoriya Georgievna BarskovaEvgeniy L'vovich NasonovA E IlyinaE I VarfolomeyevaA V VolkovE S MachE N AleksandrovaA A NovikovE V IlyinykhV G BarskovaE L NasonovAim. To estimate a relationship between the intima-media thickness (TIM), cardiovascular risk (CVR) factors, and the level of C-reactive protein (CRP) in gouty patients. Subjects and methods. Eighty-nine patients at an interattack interval were examined. The patients' mean age was 46.0 ± 11.4 years; the duration of the disease was 5.2 (3.0; 8.9) years. The traditional CVR factors were analyzed. Carotid ultrasound scanning was performed to detect vascular atherosclerotic lesion. The serum CRP concentration was measured by a highly sensitive immunonefelometric assay. Results. According to the TIM, the patients were divided into 2 groups: 1) 37 patients with signs of carotid atherosclerotic lesion (TIM l 0.9 mm); 2) 52 patients with a TIM of less than 0.9 mm. The ages at the moment of examination and at the onset of the disease, the duration of the disease, as well as systolic blood pressure, and the risk of myocardial ischemia were greater in Group 1 than those in Group 2. In patients with atherosclerosis, the concentration of CRP was statistically significantly higher than that in patients without this condition. Conclusion. By complementing the classical CVR factors, CRP may be a predictor of cardiovaskular diseases and their complications in patients with gout at an interattack interval.https://ter-arkhiv.ru/0040-3660/article/view/30524goutcardiovascular risk factorsatherosclerosisc-reactive proteinintima-media complex thickness |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
Anna Evgen'evna Il'ina Evgeniya Innokent'evna Varfolomeeva Aleksandr Viktorovich Volkov Evelina Semenovna Mach Elena Nikolaevna Aleksandrova Aleksandr Aleksandrovich Novikov Ekaterina Valerievna Il'inykh Viktoriya Georgievna Barskova Evgeniy L'vovich Nasonov A E Ilyina E I Varfolomeyeva A V Volkov E S Mach E N Aleksandrova A A Novikov E V Ilyinykh V G Barskova E L Nasonov |
spellingShingle |
Anna Evgen'evna Il'ina Evgeniya Innokent'evna Varfolomeeva Aleksandr Viktorovich Volkov Evelina Semenovna Mach Elena Nikolaevna Aleksandrova Aleksandr Aleksandrovich Novikov Ekaterina Valerievna Il'inykh Viktoriya Georgievna Barskova Evgeniy L'vovich Nasonov A E Ilyina E I Varfolomeyeva A V Volkov E S Mach E N Aleksandrova A A Novikov E V Ilyinykh V G Barskova E L Nasonov Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients Терапевтический архив gout cardiovascular risk factors atherosclerosis c-reactive protein intima-media complex thickness |
author_facet |
Anna Evgen'evna Il'ina Evgeniya Innokent'evna Varfolomeeva Aleksandr Viktorovich Volkov Evelina Semenovna Mach Elena Nikolaevna Aleksandrova Aleksandr Aleksandrovich Novikov Ekaterina Valerievna Il'inykh Viktoriya Georgievna Barskova Evgeniy L'vovich Nasonov A E Ilyina E I Varfolomeyeva A V Volkov E S Mach E N Aleksandrova A A Novikov E V Ilyinykh V G Barskova E L Nasonov |
author_sort |
Anna Evgen'evna Il'ina |
title |
Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients |
title_short |
Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients |
title_full |
Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients |
title_fullStr |
Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients |
title_full_unstemmed |
Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients |
title_sort |
relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of c-reactive protein in gouty patients |
publisher |
"Consilium Medicum" Publishing house |
series |
Терапевтический архив |
issn |
0040-3660 2309-5342 |
publishDate |
2009-10-01 |
description |
Aim. To estimate a relationship between the intima-media thickness (TIM), cardiovascular risk (CVR) factors, and the level of C-reactive protein (CRP) in gouty patients.
Subjects and methods. Eighty-nine patients at an interattack interval were examined. The patients' mean age was 46.0 ± 11.4 years; the duration of the disease was 5.2 (3.0; 8.9) years. The traditional CVR factors were analyzed. Carotid ultrasound scanning was performed to detect vascular atherosclerotic lesion. The serum CRP concentration was measured by a highly sensitive immunonefelometric assay.
Results. According to the TIM, the patients were divided into 2 groups: 1) 37 patients with signs of carotid atherosclerotic lesion (TIM l 0.9 mm); 2) 52 patients with a TIM of less than 0.9 mm. The ages at the moment of examination and at the onset of the disease, the duration of the disease, as well as systolic blood pressure, and the risk of myocardial ischemia were greater in Group 1 than those in Group 2. In patients with atherosclerosis, the concentration of CRP was statistically significantly higher than that in patients without this condition.
Conclusion. By complementing the classical CVR factors, CRP may be a predictor of cardiovaskular diseases and their complications in patients with gout at an interattack interval. |
topic |
gout cardiovascular risk factors atherosclerosis c-reactive protein intima-media complex thickness |
url |
https://ter-arkhiv.ru/0040-3660/article/view/30524 |
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