Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients

Aim. To estimate a relationship between the intima-media thickness (TIM), cardiovascular risk (CVR) factors, and the level of C-reactive protein (CRP) in gouty patients. Subjects and methods. Eighty-nine patients at an interattack interval were examined. The patients' mean age was 46.0 ± 11.4 y...

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Main Authors: Anna Evgen'evna Il'ina, Evgeniya Innokent'evna Varfolomeeva, Aleksandr Viktorovich Volkov, Evelina Semenovna Mach, Elena Nikolaevna Aleksandrova, Aleksandr Aleksandrovich Novikov, Ekaterina Valerievna Il'inykh, Viktoriya Georgievna Barskova, Evgeniy L'vovich Nasonov, A E Ilyina, E I Varfolomeyeva, A V Volkov, E S Mach, E N Aleksandrova, A A Novikov, E V Ilyinykh, V G Barskova, E L Nasonov
Format: Article
Language:Russian
Published: "Consilium Medicum" Publishing house 2009-10-01
Series:Терапевтический архив
Subjects:
Online Access:https://ter-arkhiv.ru/0040-3660/article/view/30524
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spelling doaj-0b50cd590b444d359d2a018d9eb35cc42020-11-25T03:06:08Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422009-10-018110454927551Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patientsAnna Evgen'evna Il'inaEvgeniya Innokent'evna VarfolomeevaAleksandr Viktorovich VolkovEvelina Semenovna MachElena Nikolaevna AleksandrovaAleksandr Aleksandrovich NovikovEkaterina Valerievna Il'inykhViktoriya Georgievna BarskovaEvgeniy L'vovich NasonovA E IlyinaE I VarfolomeyevaA V VolkovE S MachE N AleksandrovaA A NovikovE V IlyinykhV G BarskovaE L NasonovAim. To estimate a relationship between the intima-media thickness (TIM), cardiovascular risk (CVR) factors, and the level of C-reactive protein (CRP) in gouty patients. Subjects and methods. Eighty-nine patients at an interattack interval were examined. The patients' mean age was 46.0 ± 11.4 years; the duration of the disease was 5.2 (3.0; 8.9) years. The traditional CVR factors were analyzed. Carotid ultrasound scanning was performed to detect vascular atherosclerotic lesion. The serum CRP concentration was measured by a highly sensitive immunonefelometric assay. Results. According to the TIM, the patients were divided into 2 groups: 1) 37 patients with signs of carotid atherosclerotic lesion (TIM l 0.9 mm); 2) 52 patients with a TIM of less than 0.9 mm. The ages at the moment of examination and at the onset of the disease, the duration of the disease, as well as systolic blood pressure, and the risk of myocardial ischemia were greater in Group 1 than those in Group 2. In patients with atherosclerosis, the concentration of CRP was statistically significantly higher than that in patients without this condition. Conclusion. By complementing the classical CVR factors, CRP may be a predictor of cardiovaskular diseases and their complications in patients with gout at an interattack interval.https://ter-arkhiv.ru/0040-3660/article/view/30524goutcardiovascular risk factorsatherosclerosisc-reactive proteinintima-media complex thickness
collection DOAJ
language Russian
format Article
sources DOAJ
author Anna Evgen'evna Il'ina
Evgeniya Innokent'evna Varfolomeeva
Aleksandr Viktorovich Volkov
Evelina Semenovna Mach
Elena Nikolaevna Aleksandrova
Aleksandr Aleksandrovich Novikov
Ekaterina Valerievna Il'inykh
Viktoriya Georgievna Barskova
Evgeniy L'vovich Nasonov
A E Ilyina
E I Varfolomeyeva
A V Volkov
E S Mach
E N Aleksandrova
A A Novikov
E V Ilyinykh
V G Barskova
E L Nasonov
spellingShingle Anna Evgen'evna Il'ina
Evgeniya Innokent'evna Varfolomeeva
Aleksandr Viktorovich Volkov
Evelina Semenovna Mach
Elena Nikolaevna Aleksandrova
Aleksandr Aleksandrovich Novikov
Ekaterina Valerievna Il'inykh
Viktoriya Georgievna Barskova
Evgeniy L'vovich Nasonov
A E Ilyina
E I Varfolomeyeva
A V Volkov
E S Mach
E N Aleksandrova
A A Novikov
E V Ilyinykh
V G Barskova
E L Nasonov
Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients
Терапевтический архив
gout
cardiovascular risk factors
atherosclerosis
c-reactive protein
intima-media complex thickness
author_facet Anna Evgen'evna Il'ina
Evgeniya Innokent'evna Varfolomeeva
Aleksandr Viktorovich Volkov
Evelina Semenovna Mach
Elena Nikolaevna Aleksandrova
Aleksandr Aleksandrovich Novikov
Ekaterina Valerievna Il'inykh
Viktoriya Georgievna Barskova
Evgeniy L'vovich Nasonov
A E Ilyina
E I Varfolomeyeva
A V Volkov
E S Mach
E N Aleksandrova
A A Novikov
E V Ilyinykh
V G Barskova
E L Nasonov
author_sort Anna Evgen'evna Il'ina
title Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients
title_short Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients
title_full Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients
title_fullStr Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients
title_full_unstemmed Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients
title_sort relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of c-reactive protein in gouty patients
publisher "Consilium Medicum" Publishing house
series Терапевтический архив
issn 0040-3660
2309-5342
publishDate 2009-10-01
description Aim. To estimate a relationship between the intima-media thickness (TIM), cardiovascular risk (CVR) factors, and the level of C-reactive protein (CRP) in gouty patients. Subjects and methods. Eighty-nine patients at an interattack interval were examined. The patients' mean age was 46.0 ± 11.4 years; the duration of the disease was 5.2 (3.0; 8.9) years. The traditional CVR factors were analyzed. Carotid ultrasound scanning was performed to detect vascular atherosclerotic lesion. The serum CRP concentration was measured by a highly sensitive immunonefelometric assay. Results. According to the TIM, the patients were divided into 2 groups: 1) 37 patients with signs of carotid atherosclerotic lesion (TIM l 0.9 mm); 2) 52 patients with a TIM of less than 0.9 mm. The ages at the moment of examination and at the onset of the disease, the duration of the disease, as well as systolic blood pressure, and the risk of myocardial ischemia were greater in Group 1 than those in Group 2. In patients with atherosclerosis, the concentration of CRP was statistically significantly higher than that in patients without this condition. Conclusion. By complementing the classical CVR factors, CRP may be a predictor of cardiovaskular diseases and their complications in patients with gout at an interattack interval.
topic gout
cardiovascular risk factors
atherosclerosis
c-reactive protein
intima-media complex thickness
url https://ter-arkhiv.ru/0040-3660/article/view/30524
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