A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate Carcinoma

A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate Carcinoma

Silibinin, extracted from milk thistle (Silybum marianum L.), has exhibited considerable preclinical activity against prostate carcinoma. Its antitumor and chemopreventive activities have been associated with diverse effects on cell cycle, apoptosis, and receptor-dependent mitogenic signaling pathwa...

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Bibliographic Details
Main Authors: Ioannis Anestopoulos, Aristeidis P. Sfakianos, Rodrigo Franco, Katerina Chlichlia, Mihalis I. Panayiotidis, David J. Kroll, Aglaia Pappa
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Molecules
Subjects:
silibinin
EZH2
PRC2
histone methylation
H3K27me3
DNMT
HDAC
epigenetics
prostate cancer
Online Access:http://www.mdpi.com/1420-3049/22/1/62

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