Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation

Hepatitis delta virus (HDV) depends on the envelope proteins of hepatitis B virus (HBV) for virion production. Here, Lempp et al. produce a cell line expressing HBV envelope proteins and their receptor, which allows continuous secretion of infectious progeny HDV and testing of antiviral drugs.

Bibliographic Details
Main Authors:	Florian A. Lempp, Franziska Schlund, Lisa Rieble, Lea Nussbaum, Corinna Link, Zhenfeng Zhang, Yi Ni, Stephan Urban
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10211-2

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spelling	doaj-0b4c7b835d4c4558b301caf070bd4e812021-05-11T11:40:44ZengNature Publishing GroupNature Communications2041-17232019-05-0110111110.1038/s41467-019-10211-2Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluationFlorian A. Lempp0Franziska Schlund1Lisa Rieble2Lea Nussbaum3Corinna Link4Zhenfeng Zhang5Yi Ni6Stephan Urban7Department of Infectious Diseases, Molecular Virology, University Hospital HeidelbergDepartment of Infectious Diseases, Molecular Virology, University Hospital HeidelbergDepartment of Infectious Diseases, Molecular Virology, University Hospital HeidelbergDepartment of Infectious Diseases, Molecular Virology, University Hospital HeidelbergDepartment of Infectious Diseases, Molecular Virology, University Hospital HeidelbergDepartment of Infectious Diseases, Molecular Virology, University Hospital HeidelbergDepartment of Infectious Diseases, Molecular Virology, University Hospital HeidelbergDepartment of Infectious Diseases, Molecular Virology, University Hospital HeidelbergHepatitis delta virus (HDV) depends on the envelope proteins of hepatitis B virus (HBV) for virion production. Here, Lempp et al. produce a cell line expressing HBV envelope proteins and their receptor, which allows continuous secretion of infectious progeny HDV and testing of antiviral drugs.https://doi.org/10.1038/s41467-019-10211-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Florian A. Lempp Franziska Schlund Lisa Rieble Lea Nussbaum Corinna Link Zhenfeng Zhang Yi Ni Stephan Urban
spellingShingle	Florian A. Lempp Franziska Schlund Lisa Rieble Lea Nussbaum Corinna Link Zhenfeng Zhang Yi Ni Stephan Urban Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation Nature Communications
author_facet	Florian A. Lempp Franziska Schlund Lisa Rieble Lea Nussbaum Corinna Link Zhenfeng Zhang Yi Ni Stephan Urban
author_sort	Florian A. Lempp
title	Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
title_short	Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
title_full	Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
title_fullStr	Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
title_full_unstemmed	Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation
title_sort	recapitulation of hdv infection in a fully permissive hepatoma cell line allows efficient drug evaluation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-05-01
description	Hepatitis delta virus (HDV) depends on the envelope proteins of hepatitis B virus (HBV) for virion production. Here, Lempp et al. produce a cell line expressing HBV envelope proteins and their receptor, which allows continuous secretion of infectious progeny HDV and testing of antiviral drugs.
url	https://doi.org/10.1038/s41467-019-10211-2
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Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation

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