The Synthesis and Antiproliferative Activities of New Arylidene-Hydrazinyl-Thiazole Derivatives

The Synthesis and Antiproliferative Activities of New Arylidene-Hydrazinyl-Thiazole Derivatives

New and known arylidene-hydrazinyl-thiazole derivatives have been synthesized by a convenient Hantzsch condensation. All compounds were evaluated for their in vitro cytotoxicity on two carcinoma cell lines, MDA-MB231 and HeLa. Significant antiproliferative activity for 2-(2-benzyliden-hydrazinyl)-...

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Bibliographic Details
Main Authors: Adriana Grozav, Luiza Ioana Găină, Valentina Pileczki, Ovidiu Crisan, Luminita Silaghi-Dumitrescu, Bruno Therrien, Valentin Zaharia, Ioana Berindan-Neagoe
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:International Journal of Molecular Sciences
Subjects:
thiazole
hydrazine
cytotoxicity
DNA interaction
Online Access:http://www.mdpi.com/1422-0067/15/12/22059

Internet

http://www.mdpi.com/1422-0067/15/12/22059

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