Mutations in Epigenetic Modifiers in Myeloid Malignancies and the Prospect of Novel Epigenetic-Targeted Therapy

In the recent years, the discovery of a series of mutations in patients with myeloid malignancies has provided insight into the pathogenesis of myelodysplastic syndromes (MDSs), myeloproliferative neoplasms (MPNs), and acute myeloid leukemia (AML). Among these alterations have been mutations in gene...

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Bibliographic Details
Main Authors: Amir T. Fathi, Omar Abdel-Wahab
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Advances in Hematology
Online Access:http://dx.doi.org/10.1155/2012/469592