Alzheimer’s disease, neuroprotection, and CNS immunosenescence

This review is focused on discussing in some detail possible neuroprotective functions of microglial cells. We strive to explain how loss of these essential microglial functions might contribute towards the development of characteristic neuropathological features that characterize Alzheimer’s diseas...

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Main Authors:	Wolfgang J Streit, QingShan eXue
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2012-07-01
Series:	Frontiers in Pharmacology
Subjects:	Neuroprotection neurodegeneration Alzheimer’s disease Microglial cells CNS immunosenescence impaired neuronal protection
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00138/full

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spelling	doaj-0b485d5b0bb44685b7fb12ca80b90d322020-11-24T23:49:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122012-07-01310.3389/fphar.2012.0013822252Alzheimer’s disease, neuroprotection, and CNS immunosenescenceWolfgang J Streit0QingShan eXue1University of Florida, Mcknight Brain InstituteUniversity of Florida, Mcknight Brain InstituteThis review is focused on discussing in some detail possible neuroprotective functions of microglial cells. We strive to explain how loss of these essential microglial functions might contribute towards the development of characteristic neuropathological features that characterize Alzheimer’s disease. The conceptual framework guiding our thinking is provided by the hypothesis that microglial senescence accounts for impaired neuronal protection and consequent neurodegeneration.http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00138/fullNeuroprotectionneurodegenerationAlzheimer’s diseaseMicroglial cellsCNS immunosenescenceimpaired neuronal protection
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wolfgang J Streit QingShan eXue
spellingShingle	Wolfgang J Streit QingShan eXue Alzheimer’s disease, neuroprotection, and CNS immunosenescence Frontiers in Pharmacology Neuroprotection neurodegeneration Alzheimer’s disease Microglial cells CNS immunosenescence impaired neuronal protection
author_facet	Wolfgang J Streit QingShan eXue
author_sort	Wolfgang J Streit
title	Alzheimer’s disease, neuroprotection, and CNS immunosenescence
title_short	Alzheimer’s disease, neuroprotection, and CNS immunosenescence
title_full	Alzheimer’s disease, neuroprotection, and CNS immunosenescence
title_fullStr	Alzheimer’s disease, neuroprotection, and CNS immunosenescence
title_full_unstemmed	Alzheimer’s disease, neuroprotection, and CNS immunosenescence
title_sort	alzheimer’s disease, neuroprotection, and cns immunosenescence
publisher	Frontiers Media S.A.
series	Frontiers in Pharmacology
issn	1663-9812
publishDate	2012-07-01
description	This review is focused on discussing in some detail possible neuroprotective functions of microglial cells. We strive to explain how loss of these essential microglial functions might contribute towards the development of characteristic neuropathological features that characterize Alzheimer’s disease. The conceptual framework guiding our thinking is provided by the hypothesis that microglial senescence accounts for impaired neuronal protection and consequent neurodegeneration.
topic	Neuroprotection neurodegeneration Alzheimer’s disease Microglial cells CNS immunosenescence impaired neuronal protection
url	http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00138/full
work_keys_str_mv	AT wolfgangjstreit alzheimersdiseaseneuroprotectionandcnsimmunosenescence AT qingshanexue alzheimersdiseaseneuroprotectionandcnsimmunosenescence
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Alzheimer’s disease, neuroprotection, and CNS immunosenescence

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