Alzheimer’s disease, neuroprotection, and CNS immunosenescence

Alzheimer’s disease, neuroprotection, and CNS immunosenescence

This review is focused on discussing in some detail possible neuroprotective functions of microglial cells. We strive to explain how loss of these essential microglial functions might contribute towards the development of characteristic neuropathological features that characterize Alzheimer’s diseas...

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Bibliographic Details
Main Authors: Wolfgang J Streit, QingShan eXue
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Pharmacology
Subjects:
Neuroprotection
neurodegeneration
Alzheimer’s disease
Microglial cells
CNS immunosenescence
impaired neuronal protection
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00138/full
Description
Summary:This review is focused on discussing in some detail possible neuroprotective functions of microglial cells. We strive to explain how loss of these essential microglial functions might contribute towards the development of characteristic neuropathological features that characterize Alzheimer’s disease. The conceptual framework guiding our thinking is provided by the hypothesis that microglial senescence accounts for impaired neuronal protection and consequent neurodegeneration.
ISSN:1663-9812

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