Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice

Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice

Alveolar macrophages (AMs) are differentially regulated by human surfactant protein-A1 (SP-A1) or SP-A2. However, AMs are very heterogeneous and differences are difficult to characterize in intact cells. Using the Toponome Imaging System (TIS), an imaging technique that uses sequential immunostainin...

Full description

Bibliographic Details
Main Authors: David S. Phelps, Vernon M. Chinchilli, Judith Weisz, Lili Yang, Debra Shearer, Xuesheng Zhang, Joanna Floros
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-12-01
Series:JCI Insight
Subjects:
Immunology
Pulmonology
Online Access:https://doi.org/10.1172/jci.insight.141410

Similar Items

Similar Items