Cancer-Associated Fibroblasts’ Functional Heterogeneity in Pancreatic Ductal Adenocarcinoma

Cancer-Associated Fibroblasts’ Functional Heterogeneity in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths in the USA. Desmoplasia and inflammation are two major hallmarks of PDAC. Desmoplasia, composed of extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), and infiltrating immune and endothelial cells, acts...

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Bibliographic Details
Main Authors: Mohammad Awaji, Rakesh K. Singh
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
pancreatic cancer
PDAC
cancer-associated fibroblast
myofibroblast
inflammation
IL-6
CXCL8
TGF-β
Online Access:http://www.mdpi.com/2072-6694/11/3/290

Internet

http://www.mdpi.com/2072-6694/11/3/290

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