A specific ligand for β2-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages

A specific ligand for β2-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages

β2-Glycoprotein I (β2-GPI) is a major antigen for antiphospholipid antibodies (Abs) present in patients with the antiphospholipid syndrome (APS). We previously reported that β2-GPI specifically binds to oxidized low density lipoprotein (oxLDL), but not to native low density lipoprotein (LDL). In the...

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Bibliographic Details
Main Authors: Kazuko Kobayashi, Eiji Matsuura, Qingping Liu, Jun-ichi Furukawa, Keiko Kaihara, Junko Inagaki, Tatsuya Atsumi, Nobuo Sakairi, Tatsuji Yasuda, Dennis R. Voelker, Takao Koike
Format: Article
Language:English
Published: Elsevier 2001-05-01
Series:Journal of Lipid Research
Subjects:
autoantibody
antiphospholipid syndrome
cholesteryl ester
macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752031631X

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