Structural Features of Antitumor Titanium Agents and Related Compounds

Structural Features of Antitumor Titanium Agents and Related Compounds

Previous studies established some Ti compounds as having marked activity against tumors of the gastrointestinal tract and lack of side effects common to widely used cytostatic agents. We describe pertinent structural features of known antitumor Ti agents and other potentially active compounds. Parti...

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Main Authors: Francesco Caruso, Miriam Rossi, Cristian Opazo, Claudio Pettinari
Format: Article
Language:English
Published: Hindawi Limited 2005-01-01
Series:Bioinorganic Chemistry and Applications
Online Access:http://dx.doi.org/10.1155/BCA.2005.317
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spelling doaj-0b3923e4969c4deaa65b8e8b548267ac2020-11-24T21:25:46ZengHindawi LimitedBioinorganic Chemistry and Applications1565-36332005-01-0133-431732910.1155/BCA.2005.317Structural Features of Antitumor Titanium Agents and Related CompoundsFrancesco Caruso0Miriam Rossi1Cristian Opazo2Claudio Pettinari3Instituto di Chimica Biomolecolare, CNR, Piazzale Aldo Moro, 5, Rome 00185, ItalyVassar College, Department of Chemistry, Poughkeepsie 12604-0484, NY, USAVassar College, SCIVIS laboratory, Poughkeepsie 12604-0724, NY, USAUniversità di Camerino, Facoltà di Scienze Chimiche, Via S. Agostino 1, Camerino (MC), ItalyPrevious studies established some Ti compounds as having marked activity against tumors of the gastrointestinal tract and lack of side effects common to widely used cytostatic agents. We describe pertinent structural features of known antitumor Ti agents and other potentially active compounds. Particularly noteworthy features are that Ti-O bonds are short and Ti-O-Ti bond angles are large, demonstrating that in these compounds the O binding has high s-character approaching sp hybridization.http://dx.doi.org/10.1155/BCA.2005.317
collection DOAJ
language English
format Article
sources DOAJ
author Francesco Caruso
Miriam Rossi
Cristian Opazo
Claudio Pettinari
spellingShingle Francesco Caruso
Miriam Rossi
Cristian Opazo
Claudio Pettinari
Structural Features of Antitumor Titanium Agents and Related Compounds
Bioinorganic Chemistry and Applications
author_facet Francesco Caruso
Miriam Rossi
Cristian Opazo
Claudio Pettinari
author_sort Francesco Caruso
title Structural Features of Antitumor Titanium Agents and Related Compounds
title_short Structural Features of Antitumor Titanium Agents and Related Compounds
title_full Structural Features of Antitumor Titanium Agents and Related Compounds
title_fullStr Structural Features of Antitumor Titanium Agents and Related Compounds
title_full_unstemmed Structural Features of Antitumor Titanium Agents and Related Compounds
title_sort structural features of antitumor titanium agents and related compounds
publisher Hindawi Limited
series Bioinorganic Chemistry and Applications
issn 1565-3633
publishDate 2005-01-01
description Previous studies established some Ti compounds as having marked activity against tumors of the gastrointestinal tract and lack of side effects common to widely used cytostatic agents. We describe pertinent structural features of known antitumor Ti agents and other potentially active compounds. Particularly noteworthy features are that Ti-O bonds are short and Ti-O-Ti bond angles are large, demonstrating that in these compounds the O binding has high s-character approaching sp hybridization.
url http://dx.doi.org/10.1155/BCA.2005.317
work_keys_str_mv AT francescocaruso structuralfeaturesofantitumortitaniumagentsandrelatedcompounds
AT miriamrossi structuralfeaturesofantitumortitaniumagentsandrelatedcompounds
AT cristianopazo structuralfeaturesofantitumortitaniumagentsandrelatedcompounds
AT claudiopettinari structuralfeaturesofantitumortitaniumagentsandrelatedcompounds
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