Differential regulation of rho GTPases during lung adenocarcinoma migration and invasion reveals a novel role of the tumor suppressor StarD13 in invadopodia regulation

Differential regulation of rho GTPases during lung adenocarcinoma migration and invasion reveals a novel role of the tumor suppressor StarD13 in invadopodia regulation

Abstract Background Lung cancer is the second most commonly occurring cancer. The ability to metastasize and spread to distant locations renders the tumor more aggressive. Members of the Rho subfamily of small GTP-binding proteins (GTPases) play a central role in the regulation of the actin cytoskel...

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Bibliographic Details
Main Authors: Maria Al Haddad, Rayane El-Rif, Samer Hanna, Leila Jaafar, Rayanne Dennaoui, Sandra Abdellatef, Veronika Miskolci, Dianne Cox, Louis Hodgson, Mirvat El-Sibai
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cell Communication and Signaling
Subjects:
StarD13
Rho GTPases
Invadopodia
Migration
Invasion
Online Access:http://link.springer.com/article/10.1186/s12964-020-00635-5

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