A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses.

A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses.

A phenotypic high-throughput cell culture screen was performed to identify compounds that prevented proliferation of the human Papilloma virus type 16 (HPV-16) transformed cell line Ca Ski. A series of quinoxaline compounds exemplified by Compound 1 was identified. Testing against a panel of cell li...

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Bibliographic Details
Main Authors: Amy K Sheaffer, Min S Lee, Huilin Qi, Susan Chaniewski, Xiaofan Zheng, Glen A Farr, Kim Esposito, David Harden, Ming Lei, Liang Schweizer, Jacques Friborg, Michele Agler, Fiona McPhee, Robert Gentles, Brett R Beno, Lou Chupak, Stephen Mason
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4900674?pdf=render

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