Single-Molecule Super-Resolution Imaging of T-Cell Plasma Membrane CD4 Redistribution upon HIV-1 Binding

Single-Molecule Super-Resolution Imaging of T-Cell Plasma Membrane CD4 Redistribution upon HIV-1 Binding

The first step of cellular entry for the human immunodeficiency virus type-1 (HIV-1) occurs through the binding of its envelope protein (Env) with the plasma membrane receptor CD4 and co-receptor CCR5 or CXCR4 on susceptible cells, primarily CD4<sup>+</sup> T cells and macrophages. Altho...

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Bibliographic Details
Main Authors: Yue Yuan, Caron A. Jacobs, Isabel Llorente Garcia, Pedro M. Pereira, Scott P. Lawrence, Romain F. Laine, Mark Marsh, Ricardo Henriques
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Viruses
Subjects:
HIV-1 entry
viral receptor
nanoscale cluster
super-resolution microscopy
CD4
STORM
Online Access:https://www.mdpi.com/1999-4915/13/1/142

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