USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis

USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis

Resistance to platinum-based chemotherapy is one of the most important reasons for treatment failure in advanced non-small cell lung cancer, but the underlying mechanism is extremely complex and unclear. The present study aimed to investigate the correlation of ubiquitin-specific peptidase 22 (USP22...

Full description

Bibliographic Details
Main Authors: Aman Wang, Zhen Ning, Chang Lu, Wei Gao, Jinxiao Liang, Qiu Yan, Guang Tan, Jiwei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
ubiquitin-specific peptidase 22
DNA damage repair
apoptosis
cisplatin resistance
lung adenocarcinoma
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00274/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00274/full

Similar Items