Subacute metformin treatment reduces inflammation and improves functional outcome following neonatal hypoxia ischemia

Hypoxia-ischemia (HI) injury is a leading cause of neonatal death and long-term disability, and existing treatment options for HI offer only modest benefit. Early intervention with the drug metformin has been shown to promote functional improvement in numerous rodent models of injury and has pleiotr...

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Bibliographic Details
Main Authors: Jessica M. Livingston, Tasfia Syeda, Taryn Christie, Emily A.B. Gilbert, Cindi M. Morshead
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354620300843