Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and mutation signatures

Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and mutation signatures

Historical interbreeding between Neanderthals and humans should leave signatures of historical demographics in modern human genomes. Analysing the size distribution of Neanderthal fragments in non-African genomes suggests consistent differences in the generation interval across Eurasia, and that thi...

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Main Authors: Moisès Coll Macià, Laurits Skov, Benjamin Marco Peter, Mikkel Heide Schierup
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25524-4
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spelling doaj-0b080f9ae07b4797accda7ddfbebf81b2021-09-12T11:46:58ZengNature Publishing GroupNature Communications2041-17232021-09-0112111110.1038/s41467-021-25524-4Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and mutation signaturesMoisès Coll Macià0Laurits Skov1Benjamin Marco Peter2Mikkel Heide Schierup3Bioinformatics Research Centre, Aarhus UniversityMax Planck Institute for Evolutionary AnthropologyMax Planck Institute for Evolutionary AnthropologyBioinformatics Research Centre, Aarhus UniversityHistorical interbreeding between Neanderthals and humans should leave signatures of historical demographics in modern human genomes. Analysing the size distribution of Neanderthal fragments in non-African genomes suggests consistent differences in the generation interval across Eurasia, and that this could explain mutational spectrum variation.https://doi.org/10.1038/s41467-021-25524-4
collection DOAJ
language English
format Article
sources DOAJ
author Moisès Coll Macià
Laurits Skov
Benjamin Marco Peter
Mikkel Heide Schierup
spellingShingle Moisès Coll Macià
Laurits Skov
Benjamin Marco Peter
Mikkel Heide Schierup
Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and mutation signatures
Nature Communications
author_facet Moisès Coll Macià
Laurits Skov
Benjamin Marco Peter
Mikkel Heide Schierup
author_sort Moisès Coll Macià
title Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and mutation signatures
title_short Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and mutation signatures
title_full Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and mutation signatures
title_fullStr Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and mutation signatures
title_full_unstemmed Different historical generation intervals in human populations inferred from Neanderthal fragment lengths and mutation signatures
title_sort different historical generation intervals in human populations inferred from neanderthal fragment lengths and mutation signatures
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-09-01
description Historical interbreeding between Neanderthals and humans should leave signatures of historical demographics in modern human genomes. Analysing the size distribution of Neanderthal fragments in non-African genomes suggests consistent differences in the generation interval across Eurasia, and that this could explain mutational spectrum variation.
url https://doi.org/10.1038/s41467-021-25524-4
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AT benjaminmarcopeter differenthistoricalgenerationintervalsinhumanpopulationsinferredfromneanderthalfragmentlengthsandmutationsignatures
AT mikkelheideschierup differenthistoricalgenerationintervalsinhumanpopulationsinferredfromneanderthalfragmentlengthsandmutationsignatures
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