Leukotriene B<sub>4</sub> Receptors Are Necessary for the Stimulation of NLRP3 Inflammasome and IL-1β Synthesis in Neutrophil-Dominant Asthmatic Airway Inflammation

Leukotriene B<sub>4</sub> Receptors Are Necessary for the Stimulation of NLRP3 Inflammasome and IL-1β Synthesis in Neutrophil-Dominant Asthmatic Airway Inflammation

The stimulation of the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome and IL-1β synthesis are associated with chronic respiratory diseases such as neutrophil-dominant severe asthma. Leukotriene B<sub>4</sub> (LTB<sub>4</sub>) is a principal chemoattract...

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Bibliographic Details
Main Authors: Dong-Wook Kwak, Donghwan Park, Jae-Hong Kim
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomedicines
Subjects:
neutrophil
airway inflammation
leukotriene B4 receptors
NLRP3 inflammasome
IL-1β
Online Access:https://www.mdpi.com/2227-9059/9/5/535

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