Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)

Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)

Among current novel druggable targets, protein–protein interactions (PPIs) are of considerable and growing interest. Diacylglycerol kinase α (DGKα) interacts with focal adhesion kinase (FAK) band 4.1-ezrin-radixin-moesin (FERM) domain to induce the phosphorylation of FAK Tyr397 site and promotes the...

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Bibliographic Details
Main Authors: Jie Chen, Yan Wang, Di Zhao, Lingyuan Zhang, Weimin Zhang, Jiawen Fan, Jinting Li, Qimin Zhan
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Chrysin
Esophageal squamous cell carcinoma
DGKα
FAK
Protein–protein interactions
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520306535

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