Modification of a Putative Third Sodium Site in the Glycine Transporter GlyT2 Influences the Chloride Dependence of Substrate Transport

Modification of a Putative Third Sodium Site in the Glycine Transporter GlyT2 Influences the Chloride Dependence of Substrate Transport

Neurotransmitter removal from glycine-mediated synapses relies on two sodium-driven high-affinity plasma membrane GlyTs that control neurotransmitter availability. Mostly glial GlyT1 is the main regulator of glycine synaptic levels, whereas neuronal GlyT2 promotes the recycling of synaptic glycine a...

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Bibliographic Details
Main Authors: Cristina Benito-Muñoz, Almudena Perona, David Abia, Helena G. dos Santos, Enrique Núñez, Carmen Aragón, Beatriz López-Corcuera
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
GlyT
hyperekplexia
sodium site
neurotransmitter reuptake
SLC6
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00347/full

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