Downregulation of CD73 associates with T cell exhaustion in AML patients

Downregulation of CD73 associates with T cell exhaustion in AML patients

Abstract Background Successful treatment for acute myeloid leukemia (AML) remains challenging. Inhibiting immune checkpoint to enhance anti-tumor response is an attractive strategy for effective leukemia therapeutics. CD73 is a recently recognized immune checkpoint mediator that is highly expressed...

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Bibliographic Details
Main Authors: Yaxian Kong, Bei Jia, Chenchen Zhao, David F. Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph S. Fotos, Hui Zeng, Robert F. Paulson, K. Sandeep Prabhu, Hong Zheng
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Hematology & Oncology
Subjects:
CD73
AML
T cell exhaustion
PD-1
TIGIT
Online Access:http://link.springer.com/article/10.1186/s13045-019-0728-3

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