A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System x Mediates Aglycemic Neuronal Cell Death
The astrocyte cystine/glutamate antiporter (system x c − ) contributes substantially to the excitotoxic neuronal cell death facilitated by glucose deprivation. The purpose of this study was to determine the mechanism by which this occurred. Using pure astrocyte cultures, as well as, mixed cortical c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2015-11-01
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| Series: | ASN Neuro |
| Online Access: | https://doi.org/10.1177/1759091415614301 |