A Novel Virus-Like Particle Based Vaccine Platform Displaying the Placental Malaria Antigen VAR2CSA.

A Novel Virus-Like Particle Based Vaccine Platform Displaying the Placental Malaria Antigen VAR2CSA.

Placental malaria caused by Plasmodium falciparum is a major cause of mortality and severe morbidity. Clinical testing of a soluble protein-based vaccine containing the parasite ligand, VAR2CSA, has been initiated. VAR2CSA binds to the human receptor chondroitin sulphate A (CSA) and is responsible f...

Full description

Bibliographic Details
Main Authors:	Susan Thrane, Christoph M Janitzek, Mette Ø Agerbæk, Sisse B Ditlev, Mafalda Resende, Morten A Nielsen, Thor G Theander, Ali Salanti, Adam F Sander
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4657905?pdf=render

Similar Items

Identification of glycosaminoglycan binding regions in the <it>Plasmodium falciparum </it>encoded placental sequestration ligand, VAR2CSA
by: Theander Thor G, et al.
Published: (2008-06-01)

Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA.
by: Vera V Pinto, et al.
Published: (2011-03-01)

Identification and characterization of B-cell epitopes in the DBL4ε domain of VAR2CSA.
by: Sisse B Ditlev, et al.
Published: (2012-01-01)

Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA.
by: Pernille Andersen, et al.
Published: (2008-02-01)

Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA.
by: Sisse B Ditlev, et al.
Published: (2014-01-01)

Several domains from VAR2CSA can induce <it>Plasmodium falciparum </it>adhesion-blocking antibodies
by: Theander Thor G, et al.
Published: (2010-01-01)

The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine.
by: Morten A Nielsen, et al.
Published: (2015-01-01)

Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
by: Kaituo Wang, et al.
Published: (2021-05-01)

An upstream open reading frame controls translation of var2csa, a gene implicated in placental malaria.
by: Borko Amulic, et al.
Published: (2009-01-01)

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1.
by: Marina Ayres Pereira, et al.
Published: (2016-08-01)

Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration.
by: Madeleine Dahlbäck, et al.
Published: (2006-11-01)

The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
by: Mette Ø. Agerbæk, et al.
Published: (2018-08-01)

High avidity antibodies to full-length VAR2CSA correlate with absence of placental malaria.
by: Yeung Lo Tutterrow, et al.
Published: (2012-01-01)

Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein
by: Sara R. Bang-Christensen, et al.
Published: (2019-08-01)

Disruption of var2csa gene impairs placental malaria associated adhesion phenotype.
by: Nicola K Viebig, et al.
Published: (2007-09-01)

Structural and biochemical insights into the binding of VAR2CSA to chondroitin sulphate in placental malaria
by: Khunrae, Pongsak
Published: (2010)

VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental Malaria
by: Alice Tomlinson, et al.
Published: (2021-02-01)

Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA.
by: Dominique Dorin-Semblat, et al.
Published: (2019-06-01)

The kinetics of antibody binding to <it>Plasmodium falciparum </it>VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs
by: Arnot David E, et al.
Published: (2010-04-01)

Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade
by: Jaymin C. Patel, et al.
Published: (2017-08-01)

Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine
by: Jasmita Gill, et al.
Published: (2021-11-01)

Sequence polymorphism, segmental recombination and toggling amino acid residues within the DBL3X domain of the VAR2CSA placental malaria antigen.
by: Eldin Talundzic, et al.
Published: (2012-01-01)

Insight into antigenic diversity of VAR2CSA-DBL5ε domain from multiple Plasmodium falciparum placental isolates.
by: Sédami Gnidehou, et al.
Published: (2010-10-01)

Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates.
by: Adam F Sander, et al.
Published: (2009-08-01)

Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA.
by: Justin Doritchamou, et al.
Published: (2015-01-01)

Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in <it>Pichia pastoris</it>
by: Narum David L, et al.
Published: (2009-06-01)

Var2CSA minimal CSA binding region is located within the N-terminal region.
by: Anand Srivastava, et al.
Published: (2011-01-01)

Characterization of VAR2CSA-deficient <it>Plasmodium falciparum</it>-infected erythrocytes selected for adhesion to the BeWo placental cell line
by: Brown Graham V, et al.
Published: (2008-03-01)

Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins
by: Hathaway Marianne J, et al.
Published: (2011-02-01)

The antibody response of pregnant Cameroonian women to VAR2CSA ID1-ID2a, a small recombinant protein containing the CSA-binding site.
by: Anna Babakhanyan, et al.
Published: (2014-01-01)

Progress and Insights Toward an Effective Placental Malaria Vaccine
by: Benoît Gamain, et al.
Published: (2021-02-01)

A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice
by: Susan Thrane, et al.
Published: (2020-07-01)

Changes in <it>var </it>gene mRNA levels during erythrocytic development in two phenotypically distinct <it>Plasmodium falciparum </it>parasites
by: Theander Thor G, et al.
Published: (2007-06-01)

Plasmodium falciparum VAR2CSA-Specific IgG Subclass Responses Reflect Protection Against Low Birth Weight and Pregnancy-Associated Malaria
by: Bernard Tornyigah, et al.
Published: (2021-04-01)

Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates.
by: Marion Avril, et al.
Published: (2011-02-01)

Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin
by: Nicaise Tuikue Ndam, et al.
Published: (2015-05-01)

Differential evolution of anti-VAR2CSA- IgG3 in primigravidae and multigravidae pregnant women infected by <it>Plasmodium falciparum</it>
by: Sow Sokhna, et al.
Published: (2008-01-01)

High Antibodies to VAR2CSA in Response to Malaria Infection Are Associated With Improved Birthweight in a Longitudinal Study of Pregnant Women
by: Alistair R. D. McLean, et al.
Published: (2021-06-01)

VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placenta.
by: Eduard Rovira-Vallbona, et al.
Published: (2013-01-01)

Statistical prediction of immunity to placental malaria based on multi-assay antibody data for malarial antigens
by: Chathura Siriwardhana, et al.
Published: (2017-09-01)