4-(<i>N</i>-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition

4-(<i>N</i>-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition

To fight the increasingly worrying bacterial resistance to antibiotics, the discovery and development of new therapeutics is urgently needed. Here, we report on a new series of 1,2,4-triazole-3-thione compounds as inhibitors of metallo-β-lactamases (MBLs), which represent major resistance determinan...

Full description

Bibliographic Details
Main Authors: Laurent Gavara, Federica Verdirosa, Alice Legru, Paola Sandra Mercuri, Lionel Nauton, Laurent Sevaille, Georges Feller, Dorothée Berthomieu, Filomena Sannio, Francesca Marcoccia, Silvia Tanfoni, Filomena De Luca, Nohad Gresh, Moreno Galleni, Jean-Denis Docquier, Jean-François Hernandez
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biomolecules
Subjects:
metallo-β-lactamase
1,2,4-triazole-3-thione
bacterial resistance
β-lactam antibiotics
enzyme inhibitors
Online Access:https://www.mdpi.com/2218-273X/10/8/1094

Internet

https://www.mdpi.com/2218-273X/10/8/1094

Similar Items