Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ.
Corticosteroid-binding globulin (CBG), a negative acute phase protein produced primarily in the liver, is responsible for the transport of glucocorticoids (GCs). It also modulates the bioavailability of GCs, as only free or unbound steroids are biologically active. Fluctuations in CBG levels therefo...
Main Authors: | Nicolette Verhoog, Fatima Allie-Reid, Wim Vanden Berghe, Carine Smith, Guy Haegeman, Janet Hapgood, Ann Louw |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4205011?pdf=render |
Similar Items
-
Investigation of glucocorticoid and dissociated glucocorticoid activity in hepatoma cell lines with specific reference to regulation of the corticosteroid binding globulin (CBG) proximal promoter'
by: Allie-Reid, Fatima
Published: (2012) -
Emerging Role of Corticosteroid Binding Globulin
in Glucocorticoid-driven Metabolic Disorders
by: Marie-Pierre Moisan, et al.
Published: (2016-12-01) -
Engineering corticosteroid binding globulin to release non-glucocorticoid compounds at new sites
by: Chan, Wee Lee
Published: (2014) -
Human corticosteroid binding globulin
by: Robinson, P. A.
Published: (1984) -
The structure and function of corticosteroid-binding globulin
by: Edgar, Paul Francis
Published: (1995)