Nanoparticles Engineered as Artificial Antigen-Presenting Cells Induce Human CD4+ and CD8+ Tregs That Are Functional in Humanized Mice

Nanoparticles Engineered as Artificial Antigen-Presenting Cells Induce Human CD4+ and CD8+ Tregs That Are Functional in Humanized Mice

Artificial antigen-presenting cells (aAPCs) are synthetic versions of naturally occurring antigen-presenting cells (APCs) that, similar to natural APCs, promote efficient T effector cell responses in vitro. This report describes a method to produce acellular tolerogenic aAPCs made of biodegradable p...

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Bibliographic Details
Main Authors: Sophia Giang, David A. Horwitz, Sean Bickerton, Antonio La Cava
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
T cells
T regulatory cells
immune tolerance
systemic lupus erythematosus
graft-versus-host disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.628059/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.628059/full

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