A Validated HPLC-MS/MS Assay for 14-<i>O</i>-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] Mutilin in Biological Samples and Its Pharmacokinetic, Distribution and Excretion via Urine and Feces in Rats

A Validated HPLC-MS/MS Assay for 14-<i>O</i>-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] Mutilin in Biological Samples and Its Pharmacokinetic, Distribution and Excretion via Urine and Feces in Rats

14-<i>O</i>-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] mutilin (DPTM), a novel pleuromutilin candidate with a substituted pyrimidine moiety, has been confirmed to possess excellent antibacterial activity against Gram-positive bacteria. To illustrate the pharmacokinetic profile after intrav...

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Bibliographic Details
Main Authors: Yunxing Fu, Yu Liu, Yunpeng Yi, Jianping Liang, Qingfeng Wu, Ruofeng Shang
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
DPTM
HPLC-MS/MS
pharmacokinetics
distribution
excretion
Online Access:https://www.mdpi.com/1420-3049/24/4/790

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