Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration

Ionotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace m...

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Main Authors:	Deborah R. Morris, Cathy W. Levenson
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Journal of Toxicology
Online Access:	http://dx.doi.org/10.1155/2012/785647

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spelling	doaj-0ad31a8548a0419f9d5b7ae68052c6e32020-11-24T22:01:37ZengHindawi LimitedJournal of Toxicology1687-81911687-82052012-01-01201210.1155/2012/785647785647Ion Channels and Zinc: Mechanisms of Neurotoxicity and NeurodegenerationDeborah R. Morris0Cathy W. Levenson1Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306 4300, USADepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306 4300, USAIonotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace metal zinc. This paper discusses the role of the excitotoxic influx and accumulation of zinc, the mechanisms responsible for its cytotoxicity, and a number of disorders of the central nervous system that have been linked to these neuronal ion channels and zinc toxicity including ischemic brain injury, traumatic brain injury, and epilepsy.http://dx.doi.org/10.1155/2012/785647
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Deborah R. Morris Cathy W. Levenson
spellingShingle	Deborah R. Morris Cathy W. Levenson Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration Journal of Toxicology
author_facet	Deborah R. Morris Cathy W. Levenson
author_sort	Deborah R. Morris
title	Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration
title_short	Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration
title_full	Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration
title_fullStr	Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration
title_full_unstemmed	Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration
title_sort	ion channels and zinc: mechanisms of neurotoxicity and neurodegeneration
publisher	Hindawi Limited
series	Journal of Toxicology
issn	1687-8191 1687-8205
publishDate	2012-01-01
description	Ionotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace metal zinc. This paper discusses the role of the excitotoxic influx and accumulation of zinc, the mechanisms responsible for its cytotoxicity, and a number of disorders of the central nervous system that have been linked to these neuronal ion channels and zinc toxicity including ischemic brain injury, traumatic brain injury, and epilepsy.
url	http://dx.doi.org/10.1155/2012/785647
work_keys_str_mv	AT deborahrmorris ionchannelsandzincmechanismsofneurotoxicityandneurodegeneration AT cathywlevenson ionchannelsandzincmechanismsofneurotoxicityandneurodegeneration
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Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration

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