Vitamin E and neurodegeneration

Vitamin E and neurodegeneration

Alpha-tocopherol (vitamin E) is a plant-derived antioxidant that is essential for human health. Studies with humans and with animal models of vitamin E deficiency established the critical roles of the vitamin in protecting the central nervous system, and especially the cerebellum, from oxidative dam...

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Main Authors: Lynn M. Ulatowski, Danny Manor
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Neurobiology of Disease
Subjects:
Tocopherol
Neurodegeneration
Vitamin E
Cerebellum
Memory
Anxiety
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611500128X
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spelling doaj-0ace44eace984932bd4adfe0848722ed2021-03-22T12:42:52ZengElsevierNeurobiology of Disease1095-953X2015-12-01847883Vitamin E and neurodegenerationLynn M. Ulatowski0Danny Manor1Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USACorresponding author at: School of Medicine WG48, Case Western Reserve University, Cleveland OH 44106, USA. Tel.: +1 216 368 6230.; Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USAAlpha-tocopherol (vitamin E) is a plant-derived antioxidant that is essential for human health. Studies with humans and with animal models of vitamin E deficiency established the critical roles of the vitamin in protecting the central nervous system, and especially the cerebellum, from oxidative damage and motor coordination deficits. We review here the established roles of vitamin E in protecting cerebellar functions, as well as emerging data demonstrating the critical roles of alpha-tocopherol in preserving learning, memory and emotive responses. We also discuss the importance of vitamin E adequacy in seemingly unrelated neurological disorders.http://www.sciencedirect.com/science/article/pii/S096999611500128XTocopherolNeurodegenerationVitamin ECerebellumMemoryAnxiety
collection DOAJ
language English
format Article
sources DOAJ
author Lynn M. Ulatowski
Danny Manor
spellingShingle Lynn M. Ulatowski
Danny Manor
Vitamin E and neurodegeneration
Neurobiology of Disease
Tocopherol
Neurodegeneration
Vitamin E
Cerebellum
Memory
Anxiety
author_facet Lynn M. Ulatowski
Danny Manor
author_sort Lynn M. Ulatowski
title Vitamin E and neurodegeneration
title_short Vitamin E and neurodegeneration
title_full Vitamin E and neurodegeneration
title_fullStr Vitamin E and neurodegeneration
title_full_unstemmed Vitamin E and neurodegeneration
title_sort vitamin e and neurodegeneration
publisher Elsevier
series Neurobiology of Disease
issn 1095-953X
publishDate 2015-12-01
description Alpha-tocopherol (vitamin E) is a plant-derived antioxidant that is essential for human health. Studies with humans and with animal models of vitamin E deficiency established the critical roles of the vitamin in protecting the central nervous system, and especially the cerebellum, from oxidative damage and motor coordination deficits. We review here the established roles of vitamin E in protecting cerebellar functions, as well as emerging data demonstrating the critical roles of alpha-tocopherol in preserving learning, memory and emotive responses. We also discuss the importance of vitamin E adequacy in seemingly unrelated neurological disorders.
topic Tocopherol
Neurodegeneration
Vitamin E
Cerebellum
Memory
Anxiety
url http://www.sciencedirect.com/science/article/pii/S096999611500128X
work_keys_str_mv AT lynnmulatowski vitamineandneurodegeneration
AT dannymanor vitamineandneurodegeneration
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