Epistatic Interactions in NS5A of Hepatitis C Virus Suggest Drug Resistance Mechanisms

Epistatic Interactions in NS5A of Hepatitis C Virus Suggest Drug Resistance Mechanisms

Hepatitis C virus (HCV) causes a major health burden and can be effectively treated by direct-acting antivirals (DAAs). The non-structural protein 5A (NS5A), which plays a role in the viral genome replication, is one of the DAAs’ targets. Resistance-associated viruses (RAVs) harbouring NS5...

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Bibliographic Details
Main Authors: Elena Knops, Saleta Sierra, Prabhav Kalaghatgi, Eva Heger, Rolf Kaiser, Olga V. Kalinina
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Genes
Subjects:
hepatitis C virus
NS5A
drug resistance
epistasis
protein structure
Online Access:http://www.mdpi.com/2073-4425/9/7/343

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