Irinotecan and Δ9-Tetrahydrocannabinol Interactions in Rat Liver: A Preliminary Evaluation Using Biochemical and Genotoxicity Markers

Irinotecan and Δ9-Tetrahydrocannabinol Interactions in Rat Liver: A Preliminary Evaluation Using Biochemical and Genotoxicity Markers

There is growing interest regarding the use of herbal preparations based on Cannabis sativa for medicinal purposes, despite the poorly understood interactions of their main constituent Δ9-tetrahydrocannabinol (THC) with conventional drugs, especially cytostatics. The objective of this pilo...

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Bibliographic Details
Main Authors: Ana Lucić Vrdoljak, Nino Fuchs, Anja Mikolić, Suzana Žunec, Irena Brčić Karačonji, Andreja Jurič, Ljerka Prester, Vedran Micek, Marijana Neuberg, Samir Čanović, Gordan Mršić, Nevenka Kopjar
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
cannabinoid-based preparations
functional liver impairments
genotoxicity
hepatocytes
liver to body weight ratio
oxidative stress
Online Access:http://www.mdpi.com/1420-3049/23/6/1332

Internet

http://www.mdpi.com/1420-3049/23/6/1332

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