Electronic single-molecule identification of carbohydrate isomers by recognition tunnelling

Carbohydrates are common biological molecules, but display huge stereochemical complexity that often cannot be elucidated by mass spectrometry. Here the authors show that recognition tunnelling can distinguish individual stereoisomers, utilizing picomole quantities of analytes.

Bibliographic Details
Main Authors: JongOne Im, Sovan Biswas, Hao Liu, Yanan Zhao, Suman Sen, Sudipta Biswas, Brian Ashcroft, Chad Borges, Xu Wang, Stuart Lindsay, Peiming Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13868
Description
Summary:Carbohydrates are common biological molecules, but display huge stereochemical complexity that often cannot be elucidated by mass spectrometry. Here the authors show that recognition tunnelling can distinguish individual stereoisomers, utilizing picomole quantities of analytes.
ISSN:2041-1723