Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults

Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults

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Wnt proteins are involved in tissue development and their signaling pathways play an important role during embryogenesis. Wnt signaling can promote cell survival, which is beneficial for neurons, but could also lead to tumor development in different tissues. The present study investigated the effect...

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Bibliographic Details
Main Authors: E.M. Kawamoto, M. Gleichmann, L.M. Yshii, L. de Sá Lima, M.P. Mattson, C. Scavone
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2012-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Wnt-3a
PC12 cells
Beta-catenin
NF-κB
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100010&lng=en&tlng=en

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