In situ click chemistry generation of cyclooxygenase-2 inhibitors

Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity.

Bibliographic Details
Main Authors:	Atul Bhardwaj, Jatinder Kaur, Melinda Wuest, Frank Wuest
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-016-0009-6

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spelling	doaj-0aaf6cbf6f6f49aab5b878a4d847aa9e2021-01-31T12:34:47ZengNature Publishing GroupNature Communications2041-17232017-02-018111410.1038/s41467-016-0009-6In situ click chemistry generation of cyclooxygenase-2 inhibitorsAtul Bhardwaj0Jatinder Kaur1Melinda Wuest2Frank Wuest3Department of Oncology, University of AlbertaDepartment of Oncology, University of AlbertaDepartment of Oncology, University of AlbertaDepartment of Oncology, University of AlbertaTraditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity.https://doi.org/10.1038/s41467-016-0009-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Atul Bhardwaj Jatinder Kaur Melinda Wuest Frank Wuest
spellingShingle	Atul Bhardwaj Jatinder Kaur Melinda Wuest Frank Wuest In situ click chemistry generation of cyclooxygenase-2 inhibitors Nature Communications
author_facet	Atul Bhardwaj Jatinder Kaur Melinda Wuest Frank Wuest
author_sort	Atul Bhardwaj
title	In situ click chemistry generation of cyclooxygenase-2 inhibitors
title_short	In situ click chemistry generation of cyclooxygenase-2 inhibitors
title_full	In situ click chemistry generation of cyclooxygenase-2 inhibitors
title_fullStr	In situ click chemistry generation of cyclooxygenase-2 inhibitors
title_full_unstemmed	In situ click chemistry generation of cyclooxygenase-2 inhibitors
title_sort	in situ click chemistry generation of cyclooxygenase-2 inhibitors
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-02-01
description	Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity.
url	https://doi.org/10.1038/s41467-016-0009-6
work_keys_str_mv	AT atulbhardwaj insituclickchemistrygenerationofcyclooxygenase2inhibitors AT jatinderkaur insituclickchemistrygenerationofcyclooxygenase2inhibitors AT melindawuest insituclickchemistrygenerationofcyclooxygenase2inhibitors AT frankwuest insituclickchemistrygenerationofcyclooxygenase2inhibitors
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In situ click chemistry generation of cyclooxygenase-2 inhibitors

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