In situ click chemistry generation of cyclooxygenase-2 inhibitors

In situ click chemistry generation of cyclooxygenase-2 inhibitors

Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity.

Bibliographic Details
Main Authors: Atul Bhardwaj, Jatinder Kaur, Melinda Wuest, Frank Wuest
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-016-0009-6
Description
Summary:Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity.
ISSN:2041-1723

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