The putative effects of D-Aspartic acid on blood testosterone levels: A systematic review

Background: D-Aspartic acid (D-Asp) is in invertebrate and vertebrate neuroendocrine tissues, where it carries out important physiological functions. Recently, it has been reported that D-Asp is involved in the synthesis and release of testosterone and is assumed can be used as a testosterone booste...

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Main Authors: Farzad Roshanzamir, Seyyed Morteza Safavi
Format: Article
Language:English
Published: Shahid Sadoughi University of Medical Sciences 2017-08-01
Series:International Journal of Reproductive BioMedicine
Online Access:http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/2308/pdf
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spelling doaj-0a9a6a97baa8433282e8cedb6ec729ed2020-11-24T21:36:17ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722017-08-01151110The putative effects of D-Aspartic acid on blood testosterone levels: A systematic reviewFarzad Roshanzamir0Seyyed Morteza Safavi1Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, IranBackground: D-Aspartic acid (D-Asp) is in invertebrate and vertebrate neuroendocrine tissues, where it carries out important physiological functions. Recently, it has been reported that D-Asp is involved in the synthesis and release of testosterone and is assumed can be used as a testosterone booster for infertile men, and by athletes to increase muscle mass and strength. Objective: The aim of this review is to summarize available evidence related to the effects of D-Asp on serum testosterone levels. Materials and Methods: We conducted a systematic review of all type studies, which evaluated the effect of the D-Asp on blood testosterone including published papers until October 2015, using PubMed, ISI Web of Science, ProQuest and Scopus database. Results: With 396 retrieved records, 23 animal studies and 4 human studies were included. In vivo and in vitro animal studies revealed the effect of D-Asp depending on species, sex and organ-specific. Our results showed that exogenous D-Asp enhances testosterone levels in male animal’s studies, whereas studies in human yielded inconsistent results. The evidence for this association in man is still sparse, mostly because of limited number and poor quality studies. Conclusion: There is an urgent need for more and well-designed human clinical trials with larger sample sizes and longer duration to investigate putative effects of D-Asp on testosterone concentrations.http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/2308/pdf
collection DOAJ
language English
format Article
sources DOAJ
author Farzad Roshanzamir
Seyyed Morteza Safavi
spellingShingle Farzad Roshanzamir
Seyyed Morteza Safavi
The putative effects of D-Aspartic acid on blood testosterone levels: A systematic review
International Journal of Reproductive BioMedicine
author_facet Farzad Roshanzamir
Seyyed Morteza Safavi
author_sort Farzad Roshanzamir
title The putative effects of D-Aspartic acid on blood testosterone levels: A systematic review
title_short The putative effects of D-Aspartic acid on blood testosterone levels: A systematic review
title_full The putative effects of D-Aspartic acid on blood testosterone levels: A systematic review
title_fullStr The putative effects of D-Aspartic acid on blood testosterone levels: A systematic review
title_full_unstemmed The putative effects of D-Aspartic acid on blood testosterone levels: A systematic review
title_sort putative effects of d-aspartic acid on blood testosterone levels: a systematic review
publisher Shahid Sadoughi University of Medical Sciences
series International Journal of Reproductive BioMedicine
issn 2476-4108
2476-3772
publishDate 2017-08-01
description Background: D-Aspartic acid (D-Asp) is in invertebrate and vertebrate neuroendocrine tissues, where it carries out important physiological functions. Recently, it has been reported that D-Asp is involved in the synthesis and release of testosterone and is assumed can be used as a testosterone booster for infertile men, and by athletes to increase muscle mass and strength. Objective: The aim of this review is to summarize available evidence related to the effects of D-Asp on serum testosterone levels. Materials and Methods: We conducted a systematic review of all type studies, which evaluated the effect of the D-Asp on blood testosterone including published papers until October 2015, using PubMed, ISI Web of Science, ProQuest and Scopus database. Results: With 396 retrieved records, 23 animal studies and 4 human studies were included. In vivo and in vitro animal studies revealed the effect of D-Asp depending on species, sex and organ-specific. Our results showed that exogenous D-Asp enhances testosterone levels in male animal’s studies, whereas studies in human yielded inconsistent results. The evidence for this association in man is still sparse, mostly because of limited number and poor quality studies. Conclusion: There is an urgent need for more and well-designed human clinical trials with larger sample sizes and longer duration to investigate putative effects of D-Asp on testosterone concentrations.
url http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/2308/pdf
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