Severe ischemic colitis following olanzapine use: a Case Report

Severe ischemic colitis following olanzapine use: a Case Report

Ischemic colitis is the most common subtype of intestinal ischemia usually resulting from vasospasm, vessel occlusion or mesenteric hypoperfusion. Neuroleptics have seldom been linked to ischemic colitis by blocking peripheral anticholinergic and antiserotonergic receptors inducing severe gastrointe...

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Bibliographic Details
Main Authors: Samuel Raimundo Fernandes, Rosa Alves, Luís Araújo Correia, Ana Rita Gonçalves, João Malaquias, Emília Oliveira, José Velosa
Format: Article
Language:English
Published: Aran Ediciones
Series:Revista Espanola de Enfermedades Digestivas
Subjects:
Neuroleptics
Olanzapine
Ischemic colitis
Online Access:http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000900018&lng=en&tlng=en
Description
Summary:Ischemic colitis is the most common subtype of intestinal ischemia usually resulting from vasospasm, vessel occlusion or mesenteric hypoperfusion. Neuroleptics have seldom been linked to ischemic colitis by blocking peripheral anticholinergic and antiserotonergic receptors inducing severe gastrointestinal paresis. We report a young patient with severe ischemic colitis requiring surgery due to necrosis of the bowel. After exclusion of other potential causes, olanzapine was admitted as the cause of ischemia. Clinicians should be aware of how to recognize and treat the potentially life-threatening effects of neuroleptics.
ISSN:1130-0108

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