Sporadic amyotrophic lateral sclerosis (SALS) – skeletal muscle response to cerebrospinal fluid from SALS patients in a rat model

Sporadic amyotrophic lateral sclerosis (SALS) – skeletal muscle response to cerebrospinal fluid from SALS patients in a rat model

Skeletal muscle atrophy is the most prominent feature of amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease of motor neurons. However, the contribution of skeletal muscle to disease progression remains elusive. Our previous studies have shown that intrathecal injection of...

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Bibliographic Details
Main Authors: Shruthi Shanmukha, Gayathri Narayanappa, Atchayaram Nalini, Phalguni Anand Alladi, Trichur R. Raju
Format: Article
Language:English
Published: The Company of Biologists 2018-04-01
Series:Disease Models & Mechanisms
Subjects:
Amyotrophic lateral sclerosis
Immunohistochemistry
Electron microscopy
NMJ
Muscle atrophy
Trophic factors
Online Access:http://dmm.biologists.org/content/11/4/dmm031997

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