A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regionsResearch in context

A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regionsResearch in context

Background: Activation of brain insulin receptors modulates reward sensitivity, inhibitory control and memory. Variations in the functioning of this mechanism likely associate with individual differences in the risk for related mental disorders (attention deficit hyperactivity disorder or ADHD, addi...

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Bibliographic Details
Main Authors: Shantala A. Hari Dass, Kathryn McCracken, Irina Pokhvisneva, Lawrence M. Chen, Elika Garg, Thao T.T. Nguyen, Zihan Wang, Barbara Barth, Moein Yaqubi, Lisa M. McEwen, Julie L. MacIsaac, Josie Diorio, Michael S. Kobor, Kieran J. O'Donnell, Michael J. Meaney, Patricia P. Silveira
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419301963

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