Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics

Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics

There is growing interest in using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) derivatives for tissue regeneration. However, an increased understanding of human immune responses to stem cell-derived allografts is necessary for maintaining long-term graft persistence. To model...

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Bibliographic Details
Main Authors: Nigel G. Kooreman, Patricia E. de Almeida, Jonathan P. Stack, Raman V. Nelakanti, Sebastian Diecke, Ning-Yi Shao, Rutger-Jan Swijnenburg, Veronica Sanchez-Freire, Elena Matsa, Chun Liu, Andrew J. Connolly, Jaap F. Hamming, Paul H.A. Quax, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Joseph C. Wu
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
pluripotent stem cells
stem cell therapeutics
allograft
immunogenicity
humanized mice
T cell exhaustion
wasting disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310732

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http://www.sciencedirect.com/science/article/pii/S2211124717310732

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