Adapentpronitrile, a New Dipeptidyl Peptidase-IV Inhibitor, Ameliorates Diabetic Neuronal Injury Through Inhibiting Mitochondria-Related Oxidative Stress and Apoptosis

Adapentpronitrile, a New Dipeptidyl Peptidase-IV Inhibitor, Ameliorates Diabetic Neuronal Injury Through Inhibiting Mitochondria-Related Oxidative Stress and Apoptosis

Our previous studies indicated that adapentpronitrile, a new adamantane-based dipeptidyl peptidase-IV (DPP-IV) inhibitor, has a hypoglycemic effect and ameliorates rat pancreatic β cell dysfunction in type 2 diabetes mellitus through inhibiting DPP-IV activity. However, the effect of adapentpronitri...

Full description

Bibliographic Details
Main Authors: Lu Yang, Wenli Han, Ying Luo, Xiangnan Hu, Ying Xu, Huan Li, Congli Hu, Dan Huang, Jie Ma, Yang Yang, Qi Chen, Yuke Li, Jiahua Zhang, Hui Xia, Zhihao Chen, Hong Wang, Dongzhi Ran, Junqing Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
adapentpronitrile
DPP-IV inhibitor
neuron injury
mitochondrial apoptosis pathway
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00214/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00214/full

Similar Items