Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity

Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity

Hypoxia, or gradients of hypoxia, occurs in most growing solid tumors and may result in pleotropic effects contributing significantly to tumor aggressiveness and therapy resistance. Indeed, the generated hypoxic stress has a strong impact on tumor cell biology. For example, it may contribute to incr...

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Bibliographic Details
Main Authors: Stéphane Terry, Rania Faouzi Zaarour, Goutham Hassan Venkatesh, Amirtharaj Francis, Walid El-Sayed, Stéphanie Buart, Pamela Bravo, Jérome Thiery, Salem Chouaib
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
tumor microenvironment
tumor heterogeneity
cancer
cancer stem cells
EMT
cell plasticity
DNA damage and repair
immune evasion
HIF
Online Access:http://www.mdpi.com/1422-0067/19/10/3044

Internet

http://www.mdpi.com/1422-0067/19/10/3044

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