CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter

CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter

Summary: Correct positioning of T cells within infected tissues is critical for T cell activation and pathogen control. Upon tissue entry, effector T cells must efficiently locate antigen-presenting cells (APC) for peripheral activation. We reveal that tissue entry and initial peripheral activation...

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Bibliographic Details
Main Authors: Hen Prizant, Nilesh Patil, Seble Negatu, Noor Bala, Alexander McGurk, Scott A. Leddon, Angela Hughson, Tristan D. McRae, Yu-Rong Gao, Alexandra M. Livingstone, Joanna R. Groom, Andrew D. Luster, Deborah J. Fowell
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
CD4 T cells
Th1
chemokine
CXCL10
CXCR3
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721009542

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