Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds

Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds

Methods to prepare small, strained rings are sought after due to the importance of such scaffolds in medicinal chemistry. Here, the authors report a palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl and azetidinyl esters.

Bibliographic Details
Main Authors: Zhi-Tao He, John F. Hartwig
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12090-z
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spelling doaj-0a82f86cdee2462bac4e2ef54fef7ea52021-05-11T12:21:06ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-12090-zPalladium-catalyzed α-arylation for the addition of small rings to aromatic compoundsZhi-Tao He0John F. Hartwig1Department of Chemistry, University of CaliforniaDepartment of Chemistry, University of CaliforniaMethods to prepare small, strained rings are sought after due to the importance of such scaffolds in medicinal chemistry. Here, the authors report a palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl and azetidinyl esters.https://doi.org/10.1038/s41467-019-12090-z
collection DOAJ
language English
format Article
sources DOAJ
author Zhi-Tao He
John F. Hartwig
spellingShingle Zhi-Tao He
John F. Hartwig
Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
Nature Communications
author_facet Zhi-Tao He
John F. Hartwig
author_sort Zhi-Tao He
title Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
title_short Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
title_full Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
title_fullStr Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
title_full_unstemmed Palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
title_sort palladium-catalyzed α-arylation for the addition of small rings to aromatic compounds
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description Methods to prepare small, strained rings are sought after due to the importance of such scaffolds in medicinal chemistry. Here, the authors report a palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl and azetidinyl esters.
url https://doi.org/10.1038/s41467-019-12090-z
work_keys_str_mv AT zhitaohe palladiumcatalyzedaarylationfortheadditionofsmallringstoaromaticcompounds
AT johnfhartwig palladiumcatalyzedaarylationfortheadditionofsmallringstoaromaticcompounds
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