Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation

Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation

The opportunistic fungal pathogen Cryptococcus neoformans causes life-threatening meningitis in immunocompromised individuals. The expression of virulence factors, including capsule and melanin, is in part regulated by the cyclic-AMP/protein kinase A (cAMP/PKA) signal transduction pathway. In this s...

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Bibliographic Details
Main Authors: J. M. H. Geddes, M. Caza, D. Croll, N. Stoynov, L. J. Foster, J. W. Kronstad
Format: Article
Language:English
Published: American Society for Microbiology 2016-01-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/1/e01862-15

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