Zinc enhances hippocampal long-term potentiation at CA1 synapses through NR2B containing NMDA receptors.

Zinc enhances hippocampal long-term potentiation at CA1 synapses through NR2B containing NMDA receptors.

The role of zinc (Zn2+), a modulator of N-methyl-D-aspartate (NMDA) receptors, in regulating long-term synaptic plasticity at hippocampal CA1 synapses is poorly understood. The effects of exogenous application of Zn2+ and of chelation of endogenous Zn2+ were examined on long-term potentiation (LTP)...

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Bibliographic Details
Main Authors: John A Sullivan, Xiao-Lei Zhang, Arthur P Sullivan, Linnea R Vose, Alexander A Moghadam, Victor A Fried, Patric K Stanton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0205907

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