Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats

Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats

Oxaliplatin is a key drug used in the management of solid tumors, such as colorectal cancer; however, it causes peripheral neuropathy. In this study, we investigated the effect of ibudilast, a phosphodiesterase inhibitor, on oxaliplatin-induced mechanical allodynia and histological changes in rats....

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Bibliographic Details
Main Authors: Nobuaki Egashira, Yu Goto, Ryota Takahashi, Hikari Iba, Shota Yamamoto, Takuya Watanabe, Kaori Kubota, Takehiro Kawashiri, Chise Taniguchi, Shutaro Katsurabayashi, Katsunori Iwasaki
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Journal of Pharmacological Sciences
Subjects:
Ibudilast
Oxaliplatin
Peripheral neuropathy
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000608

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